Denosumab

BUS 690 Case #2: Forecasting Denosumab Amgen was champion of the human beingss leading biotechnology companies, with more than 17,000 employees and almost $15 billion in revenue. Amgens most important drugs bring home the bacon in: * Aranesp-anemia; declining sharply * Epogen-anemia * Enbrel-arthritis * Neulasta-febrile neutropenia, a condition associated with chemotherapy Amgen has developed a new yield called Denosumab under brand names Prolia and Xgeva, and had patents that were schedule to expire betwixt 2017 and 2023. Prolia treats Osteoporosis, a prepare disorder, common still serious condition. Xgeva seeks to go along skeletal-related events from occurring in cancer patients with bone metastases. Prolia Osteoporosis is diagnosed by BMDbone mineral density mental test, the primordial BMD test was dual-energy X-ray absorptiometry (DXA); a BMD test costs $50 per patient. Amgen priced Prolia at $825 per injection, or $1,650 per year . There is a total of 30.7 one thousand gazillion people in the U.S. with osteoporosis or osteopenia, and 15.5 million (49%) were diagnosed, only a portion of that group received intervention. 40% of patients receiving interference continued to see declining BMD levels, and 5% had fractures.

Aside from sermon options of exercise and dietary supplements, bisphosphonates are the main class of drugs for the word of osteopenia and osteoporosis in early 2011, made from two phosphonic groups. The drugs worked by deliberateness the breakdown of bone by osteoclasts, resulting in an increase in BMD and a dec rease in fractures. Despite the strong i! ngenuity of bisphosphonates, compliance was low; studies indicated that about 50% of patients discontinued oral examination examination bisphosphonate therapy within the first year. Prolias competition: | U.S. sales (mil) | division| Boniva| $600.00 | 2008| Reclast| $579.00 | 2010| Evista| $682.00 | 2009| Forteo| $518.00 | 2009| Total U.S. sales of competitors:| $2,379.00 | | Prolia is administered by...If you want to get a well(p) essay, order it on our website: OrderCustomPaper.com

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